Endometrial cycle: phases
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The beginning of the endometrial cycle coincides with the loss of epithelium1 with menstruation and only a thin layer of epithelium persists. The endometrium suffers, thanks to the action of hormones, a series of important modifications destined to make possible the implantation of the fertilized ovum.
Phases of the endometrial cycle
Are distinguished Two phases of the endometrial cycle: the proliferative phase and the secretory phase.
Proliferative phase
- It extends from the end of menstruation until ovulation. At the beginning of this phase, the endometrial mucosa is thinned and with a few glands.
- The proliferative phase is parallel to the ovarian follicular phase and under the influence of estrogens the thickness of the endometrium increases 3 to 10 times its initial volume. At the end of the proliferative phase, the mean height of the endometrium is about 6-8 mm and they begin to form endometrial glands.
Secretory phase
The secretory phase is influenced by the progesterone production in the body luteum2. As the endometrial thickness does not increase but the glands proliferate, they must acquire a very tortuous appearance and begin to secrete a thick liquid rich in nutrients to prepare for the implantation of the fertilized ovum. At the end of the secretory phase, between days 25 and 28 of the cycle, the premenstrual phase, in which the decrease in hormonal levels produces an involution of the elements that had undergone a hormone-dependent development.
Menstruation occurs as a consequence of all the cyclical modifications that the endometrium undergoes to adapt to a possible implantation.
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Specialist in gynecology and obstetrics
(Updated at Apr 15 / 2024)