Diprogenta: what it is, how it is used, and side effects.

A drug with Antibacterial properties used for skin diseases.

The skin is a very important part of our organism. But as with the rest of the parts of our body, it is susceptible to injuries, diseases and various infections, being necessary to resort to medicine to alleviate and cure the ailments that may occur.

As we already know, there are a large number of creams and drugs designed for the treatment of dermatological problems. One of them is diprogentawhich we are going to talk about in this article.

Diprogenta: what is it?

Diprogenta is a powerful drug with numerous effects on the human skin and which is used in the treatment of various skin diseases. It is a substance composed mainly of betamethasone dipropionate and gentamicin sulfate, the former being a type of corticosteroid and the latter an aminoglycoside antibiotic with effect on different bacteria.

These components make diprogenta have anti-inflammatory, bactericidal and vasoconstrictor effects as well as reducing itching, although its use should not exceed two weeks because prolonging the treatment with this substance in excess can generate important side effects (especially due to the use of corticoids).

Its action is relatively fast and its effects are prolonged in time, and it can generally be applied once or twice a day. It is a drug that is marketed in the form of a cream. is marketed in the form of a creamIt should be applied on healthy skin (never on wounds) and there is no other route of administration other than cutaneous, since it is the route by which it is best metabolized.

Caution must be taken to avoid ingestion, as well as to avoid contact with the eyes. The dosage will have to be indicated by the physician in each case, although it is generally indicated to spread a thin layer of this drug.

Indications

Diprogenta is a very useful drug in the treatment of various skin conditions, especially those lesions and inflammations complicated with a subsequent secondary infection. infection.

It is commonly used in dermatoses (generic name for skin diseases), among which is its use in case of dermatitis (whether atopic, solar, seborrheic, contact, poisonous or exfoliative), eczema, allergic reactions or psoriasis, reducing inflammation and soothing itching and discomfort as well as treating possible infections sensitive to the action of gentamicin.

Of course, this product has bactericidal properties, but not antifungal, so it will not be effective in psoriasisTherefore, it will not be effective in fungal diseases such as candidiasis.

Side effects

As we have indicated above, diprogenta is a potent drug whose use must be restricted in time and applied in a very limited way, since it can give rise to different side effects and even intoxication.

Among the side effects resulting from excessively prolonged use are and in very large areas of the body include atrophy and cracking of the skin, dryness or maceration of the skin (weakening and softening of the skin), inflammation of hair follicles, allergic reactions, infections, redness, acne and skin eruptions, stretch marks or the appearance of hair.

Other more serious side effects include alterations not only in the skin but also in other systems and even in the development process in children (growth may be retarded): can generate the suppression of the hypothalamus-pituitary-adrenal axis, hyperglycemia (of great severity especially in diabetic patients), blood and intracranial hypertension, worsening of glaucoma, hyperthyroidism, cholesterol, ulcer, cataracts, blurred vision, alopecia, drop in blood potassium level or even Cushing's syndrome. It can also generate affectation at renal and hepatic level, being its prolonged use toxic.

In addition, tolerance to gentamicin may also occur, tolerance to gentamicin may also occur, facilitating subsequent gentamicin-resistant infections.which would facilitate subsequent infections resistant to this antibiotic.

Contraindications and precautions

Diprogenta is a very potent drug that has a large number of side effects if misused, and there are also a number of contraindications and precautions that must be taken into account before prescribing it.

It is contraindicated in children under twelve years of age, and its use in those who have reached that age should be made with great caution due to the possible alteration of the endocrine and hormonal system, since it could have and hormonal system as it could have important effects on their development.

It is also contraindicated in the case of pregnant women (especially in the first trimester) and nursing mothers unless the benefits outweigh the possible risks, since although there is not enough data in humans, it has been demonstrated that it can generate alterations in the fetus in rats.

Obviously this product should not be used if you are allergic to its components. It should not be used in case of fungal or viral infections, tuberculosis or syphilis.It should also not be used in case of tuberculosis or syphilis, in oral, ocular or genital inflammations, in reactions to vaccines or in deep wounds.

It should also be avoided to use this product in large areas, its use in areas covered with bandages or in areas of the skin with a large number of folds, and its prolonged use should be especially avoided. Its use in psoriasis, although it may be an indication for diprogenta, should be extremely controlled and under supervision. Finally, it is not recommended to mix it with substances that may interact with it.

Bibliographic references:

• Spanish Agency of Medicines and Health Products (2012). Package leaflet: information for the user. Diprogenta 0.5mg/g +1mg/g cream. Madrid, Spain. Government of Spain; Ministry of Health, Social Services and Equality.