Suxidine: uses and side effects of this drug

This drug is used to treat alterations of the digestive tract generated by stress.

Gastrointestinal symptoms are some of the most frequent manifestations when we are exposed to excessive nervous tension. To treat these manifestations there are numerous remedies, including pharmacology.

Precisely suxidine is a drug used to treat diseases of the digestive tract related to major stressful situations. related to important situations of stress. We will see below the main characteristics of this drug, as well as some recommendations in case of use.

What is suxidine?

Suxidine is a drug used to treat different symptoms of the digestive system, related to states of anxiety. It contains the following chemical compounds: talc, colloidal silica, calcium carbonate, methylene casin, magnesium stearate, dibasic calcium phosphate, casin.

It has mild anxiolytic properties, as a result of one of its active ingredients, Oxazepam Hemisuccinate.. The latter acts quickly and is almost completely absorbed, without the intervention of food. It is a chemical compound of low toxicity, which usually remains in the system for 8 hours and is eliminated by the liver.

It also contains metoclopramide hydrochloride, which acts as a motility acts as a regulator of Gastrointestinal motility and prevents spasms of the gastrointestinal tract.. It is absorbed by the digestive tract and metabolized by the liver after approximately 4 hours. Metoclopramide has a slightly higher toxicity, capable of generating digestive and nervous disorders, especially in children.

It also contains polienzim-S, a compound of synthetic digestive enzymes and protein nature, which interact with natural enzymes, the digestion process.. Finally, suxidine contains anti-foaming silicone, which serves to reduce intestinal gas without significantly modifying the gastric pH.

Authorization status in Spain

In Spain, suxidine in tablet form was authorized for marketing on February 1, 1974, by SEID, S.A. laboratories.

This authorization has been revoked as of July 27, 2018, so it is not currently marketed in that country. However, in other countries its distribution may continue to be in force, so we will see below some uses and characteristics of this drug.

What is this drug used for and how is it taken?

Suxidine usually in tablet form and by prescription.. The average dose for adults is 3 to 6 daily. In the case of children, it is contraindicated for children under 11 years of age.

Likewise, this drug is indicated to treat the following clinical manifestations associated with acute stress and anxiety:

1. neurovegetative dystonia.

Also known as dysautonomia. Dystonia are movement disorders that affect muscle contractions. As the term itself indicates, neurovegetative dystonia affects the vegetative nervous system, which is responsible for regulating involuntary movements, for example those of the digestive system. It is characterized by an acceleration or slowing of the organs that make up the digestive system..

2. Nervous dyspepsia

Dyspepsias are motility disorders of the digestive system, specifically affecting the upper gastrointestinal tract. They impair the secretion of this organ and cause pain, bloating and stomach irritation. It is called nervous dyspepsia because it has a psychogenic origin.

3. Neurosensitive-motor dyspepsia

Like the previous one, it is a motility disorder of the digestive system, but in this case, the origin of the disorder may be linked to the activity of the digestive system. may be linked to the activity of the sensory nervous system and the activity of the sensory nerves. and the activity of the sensory nerves.

4. Dystonic biliary dyskinesia

Affectation of biliary motility, specifically excessive or inappropriate movements of the muscles that regulate bile secretion.

5. Neurogenic gastritis

Also known as nervous gastritis, since its origin is prolonged and intense exposure to stressful situations. Gastritis is characterized by the inflammation of the mucous membrane that lines the stomach and protects it from acidity.

6. Gastroenteritis

It is an inflammation of the internal membrane that lines both the stomach and the intestine, i.e. it causes swelling of the intestinal tract, resulting in diarrhea, vomiting and pain. It is generally caused by the activity of viruses and bacteria..

7. Gastroduodenal ulcer

Also known as peptic ulcer, it is a localized sore on the a localized sore in the inner membrane of the stomach or the first part of the small intestine.. It occurs due to a rupture of this membrane and can be caused by bacteria or other diseases, as well as by alcohol consumption, drugs, tobacco or stress.

8. Irritable colon

Functional disorder of the digestive system that mainly affects the activity of the intestine, generating abdominal pain, constipation, diarrhea and other symptoms.

Contraindications and side effects

Its use should be avoided in people whose gastric motility may worsen under the intake of this drug. For example, people who have hemorrhages, obstruction or perforation in any organ of the digestive system. It is also contraindicated in is contraindicated in people with tardive dyskinesia or neuroleptic dyskinesia (motor disorder related to the prolonged intake of some neuroleptic drugs).

In addition, it can potentiate the antidopaminergic effects in the central nervous system and the sedative effects of many substances, so its combination with phenothiazines, tranquilizers, hypnotics, narcotics and alcohol should be avoided. On the other hand, its action decreases when it interacts with other active ingredients such as digoxin and cimetidine..

It is not advisable to use it during pregnancy and lactation period, and it is also recommended to avoid situations that require an active state of alertness, due to its sedative effects.

Among the most common side effects is drowsiness, and in elderly people, prolonged use may cause tardive dyskinesia. The latter are the effects that can be caused by an overdose of this drug. an overdose of this drug can cause..

Similarly, prolonged treatment can cause breast tension, galactorrhea (milk production out of period), amenorrhea (absence of menstruation for more than 90 days), gynecomastia (breast enlargement in males), impotence and hyperprolactinemia (increased prolactin levels in the blood).

As for more serious reactions, extrapyramidal reactions such as muscle spasms of the face, neck and tongue have been observed in children and adolescents.

Bibliographic references:

• Suxidine Tablets. Authorization Status (2018). Spanish Agency for Medicines and Health Products. Retrieved September 07, 2018. Available at https://www.aemps.gob.es/cima/publico/lista.html.
• Suxidine Comp. Medication Canceled. (2018). Vademecum. Retrieved September 07, 2018. Available at https://www.vademecum.es/medicamento-suxidina_3781.
• Suxidine. Factsheet (S/A). Botplusweb. Retrieved 07 September 2018. Available at https://botplusweb.portalfarma.com/documentos/FICHAS%20TECNICAS%20POR%20LABORATORIOS%20PDF/Seid/f52063%20Suxidina.PDF.