Thioproperazine: uses and side effects of this antipsychotic drug.

A psychotropic drug used in some cases of psychotic symptoms or epilepsy.

Thioproperazine is a typical antipsychotic, also known as a neuroleptic.also known as a neuroleptic, which as such acts by blocking some neurotransmitter receptors such as those in charge of dopamine regulation, which is associated with the reduction of typical manifestations of schizophrenia.

In this article we will see what thioproperazine is and what it is used for, as well as some of its indications and possible adverse effects.

What is thioproperazine and what is it used for?

Thioproperazine is a drug that belongs to the category of antipsychotics.. The latter includes chemical compounds that are used especially to eradicate some typical manifestations of the diagnosis of schizophrenia, but also to treat symptomatology associated with bipolar disorders, both in episodes of mania and depression, obsessive-compulsive disorders and some manifestations of dementia.

Mechanism of action

Thioproperazine acts by blocking dopaminergic receptors in the central nervous system.. In this way, it has neuroleptic effects and blocks some thoughts, including delusions and hallucinations. For the same reason, the other term by which this type of medication has traditionally been known is neuroleptic.

Such neuroleptic action produces a potent effect on manic arousal, so that thioproperazine is considered effective in the treatment of motor excitation seizures, both in the course of some types of schizophrenia and in the case of some types of epilepsy. in the case of some types of epilepsy..

This is because thioproperazine acts on the central nervous system, more specifically on the ascending reticular system, the ascending reticular system, the ascending reticular system and the ascending reticular system. the ascending reticular system, the limbic system and the hypothalamus, which are subcortical subcortical centers.which are fundamental subcortical centers for the activation of various human faculties.

Precisely, the drawback of these drugs is that they have a high probability of causing serious adverse reactions that significantly alter some dimensions of the life of the person who has the diagnosis. This is a type of medication with a high risk of toxicity, so that their use requires strict medical supervisionIt is no longer marketed in some countries.

Presentation and dosage

Thioproperazine is marketed under the name Majeptil. Its composition is in 10 mg tablets for oral administration.. Such administration depends on the characteristics and medical history of each person, however, 2 or 3 daily intakes of 30-40 mg are generally prescribed, which are reached progressively.

Considerations and precautions for this drug

The general recommendation was to maintain vigilance in the case of a history of liver disease as well as in cases of epilepsy and serious Cardiovascular diseases, due to the high risk of causing ventricular arrhythmias. risk of causing severe ventricular arrhythmias..

Thioproperazine is contraindicated in combination with respiratory center depressants and antihypertensives. Its absorption in the organism can be decreased when interacting with some common compounds such as salts, oxides and different hydroxides. Likewise, it increases the depressant action of the central nervous system when mixed with other sedatives, chemical compounds derived from morphine, barbiturates, hypnotics, methadone, clonidine and anxiolytics.

Regarding the risks of use during pregnancy there are no studies, so their use is not recommended, especially after the last trimester of the gestational period. The same applies to its use during lactation.

Finally, since it produces a significant alteration of the state of wakefulness and drowsiness, it is important to take precautions when driving or handling heavy machinery.

Possible side effects

As mentioned above, the high probability of generating serious adverse reactions has led to the substitution of this substance by other drugs that have similar functions, with less risk of toxicity.

The effects of reducing delirium and hallucinations are related to the blockade of the dopamine centers. are related to the blockade of the dopaminergic centers of the limbic system caused by thioproperazine. In turn, adverse effects related to the nervous system, such as extrapyramidal syndrome, are related to the blockade of the striatum.

Some of the adverse effects of thioproperazine include the following:

• Severe cardiovascular disease..
• Epileptic seizures, especially when there has been a history prior to treatment.
• Weight loss and impaired glucose tolerance.
• Hepatic or renal insufficiency due to risk of overdosage.

Extrapyramidal syndrome may also appear, which is characterized by inability to express oneself by mimicry or gestures, some Parkinson's-like manifestations, a particular type of gait leaning forward, without brachiation and with small steps, muscle rigidity, coarse tremor during the resting state.

Bibliographic references:

• Spanish Agency of Medicines and Health Products (2007). Antipsychotics. Review of safety in the treatment of psychotic symptoms associated with dementia. Retrieved August 16, 2018. Available at https://www.aemps.gob.es/informa/notasInformativas/medicamentosUsoHumano/seguridad/2008/docs/informe_antipsicoticos_CSMH_2007.pdf.
• Botplusweb (1999). Majeptil. Fact Sheet. Retrieved August 16, 2018. Available at https://botplusweb.portalfarma.com/documentos/FICHAS%20TECNICAS%20POR%20LABORATORIOS%20PDF/Aventis%20Pharma/f36000%20Majeptil.PDF.
• Spanish Agency of Medicines and Health Products (S/A). Use of antipsychotics in Spain (1992-2006). Retrieved August 16, 2018. Available at https://www.aemps.gob.es/medicamentosUsoHumano/observatorio/docs/antipsicoticos.pdf.