Buy Nizonide (Nitazoxanide) for Effective Parasitic Infection Treatment

Generic Nizonide (Nitazoxanide 500 mg) Medication guide:

Nizonide is an anti-infective medicine. It is used to reduce the symptoms of diarrhea in children and adults caused by certain parasites that live in the intestines. This medication should not be used to treat diarrhea that is caused by bacteria.

Usage and Dosage

You should take nitazoxanide with food. Liquid nizonide should be taken with food to improve the body's absorption of the medicine. Shaking the medicine before taking it will help ensure the proper dosage. If any liquid nitazoxanide is accidentally spilled, it should be cleaned immediately with a disinfectant, as nitazoxanide may stain clothing, fabrics, and surfaces. Liquid nitazoxanide should be taken with the help of the bottle's oral dosing syringe. Don't use a common tablespoon to measure liquid nitazoxanide. Your doctor will tell you how much nitazoxanide to also take and how often to take it.

When taking nitazoxanide for the treatment of cryptosporidiosis, your doctor will tell you how long to take it once per day. Symptoms of dehydration, such as urinating less frequently than usual, dry mouth, and no tears when crying, are commonly associated with cryptosporidiosis. Due to the elevated risk of dehydration, it is likely that your doctor will want to keep you on a rehydration schedule during the early stages of treating your condition. Ask your pharmacist if you have any further questions about nitazoxanide, or internet sources of data.

Administration Instructions

Different formulations of nitazoxanide may be used to treat different parasitic infections. Use nitazoxanide only for the condition for which it was prescribed. Do not use nitazoxanide for asymptomatic infection. Nizonide tablets are not for use in children less than 4 years of age. Nizonide oral suspension is not for use in children less than 1-year-old.

• Shake the oral suspension well before each use;
• Have your child swallow the oral suspension. Don't give the oral suspension in the child's cheek. Don't let the oral suspension touch your child's teeth as it may cause teeth staining;
• Feed your baby immediately after giving the oral suspension;
• Check the label on the packaging for the recommended dose form, concentration, and amount of Nizonide oral suspension and the number of final ml or teaspoons to give for each dose that is measured. Use the dropper provided to measure your child's recommended dose on the dropper. The dropper may have 2 measurements on it: ml and teaspoons, representing 2 different concentrations. You can measure your child's recommended dose according to the 2 different concentration amounts on the dropper. Choose the line for the concentration of Nizonide suspension prescribed for your child and measure your child's dose to the nearest ml or teaspoon, based on the prescription dosage given by your doctor or pharmacist. After use, wash and dry the dropper.

The duration of Nizonide treatment is typically: Adults and children 12 years at least: 500 mg twice daily for 3 days. Children 4 through 11 years: 200 mg twice daily for 3 days. If a dose of Nizonide oral suspension is missed, for the best antiprotozoal activity, it should be given as soon as possible. However, if it is almost time for the next dose, skip the dose you missed and take only the next regular scheduled dose.

Precautions and Warnings

Drug interactions were reported in patients with dietary supplements such as retinol in children. Do not take any dietary supplements that contain retinol (vitamin A) or foods high in vitamin A while taking Nizonide. Do not take Nizonide with ingredients such as 2 T-WA and CI 800 that reduce absorption of fat-soluble vitamins in patients with foods high in fat and meal absorption and other drug therapies due to drug interactions. Side effects of Nizonide include abdominal pain, chills, lack of appetite, rapidly elevated liver enzymes in the blood, including watery diarrhea, and dark urine coloring. Other side effects not listed may also occur in the case of a poison. If it is out of your control, notify your doctor of the symptoms for medication safety. Patient safety should be taken to avoid medication overdose and underdose problems. Nitazoxanide Medication Guide such as a cup with tablets or oral suspension, a measuring syringe, or dosing cup. Community with pediatric knowledge, therapists, and resources.

Nitazoxanide is a broad-spectrum antiparasitic and broad-spectrum antiviral. It is FDA-approved for the treatment of diseases caused by protozoa with the ease of use of oral therapy. Nitazoxanide prevents growth and reproduction of parasites and kills the parasites in the intestines. The FDA approved nitazoxanide 100 mg for children 1 year of age and older and weighing 6 kg to 17 kg. Nizonide (Cipla) in this form is available as an apple-flavored liquid. It is available as tablets in strengths of 200 mg, 300 mg, and 500 mg. Nitazoxanide is effective against Cryptosporidium, Giardia, Entamoeba histolytica, Cystoisospora belli, Cyclospora cayetanensis, and Blastocystis hominis and presumed to be effective against some enteric helminths such as soil-transmitted helminth species when co-infecting with protozoa. Patients should take with food such as biscuits, bread, banana, applesauce, or yogurt or with an oral rehydration solution such as Pedialyte, Renasol, Elyte. Drink enough fluid 30 minutes after taking Nizonide. A single day treatment of Nizonide 100 mg provides an average 68.5% cure rate and 10 mg Nitazoxanide in an average 83% cure rate. However, in 2014 interacting with solutions and hardeners and accompanying malabsorption ion S and H S-E2 inhibitors were not used concurrently treated with thi I-based antiretroviral therapy in adults. Proper disposal of Nitazoxanide Nitazoxanide is a USFDA-approved medication. Dispose of any unused and expired medicine properly according to your local guidelines.

Allergic Reactions

Nizonide (Generic Nitazoxanide) is registered as an antibacterial in Nigeria by the National Agency for Food and Drug Administration and Control, a regulatory agency of the Federal Government of Nigeria. It is a yellow, crystalline powder with a melting point of approximately 200-210°C. Application of Nizonide (Nitazoxanide) powder in Nizonide Tablet Formulation (125 mg, 250 mg, and 500 mg) mouth part instead of the syrup formulation, and Nizonide (Nitazoxanide) administered to humans at doses of 50 mg/kg/day to 100 mg/kg/day, demonstrates the usefulness of Nizonide (Nitazoxanide) powder in the manufacturing process.

Drug Interactions

This medication administration guide is just a summary and not detailed at all. It does not fully explain the use of drug. Ask your healthcare provider for comprehensive information on this drug and its use. Do not use Nizonide (Nitazoxanide) for a disease any other than the one for which it was prescribed. Do not give Nizonide (Nitazoxanide) to other people or write on their paper a description for someone else, even though they have the same symptoms that you do. Using the Nizonide (Nitazoxanide) could be dangerous for people, but it has not been prescribed. If you are to have an operation or to be hospitalize, inform all doctors, dentists and any healthcare provider who is caring for you that you are taking Nizonide (Nitazoxanide) or that you have just ended the treatment with this drug.

It is important to tell your prescriber about any medicines you are already using, including over-the-counter medicines (those that do not require a prescriber's permission), vitamins, and herbal and alternative medicines. Medicine interactions are possible and may be harmful. Nizonide can affect other drugs badly, and other drugs can influence Nizonide. Following drugs are likely to interact and should not be prescribed while taking Nizonide: I-antithrombotic agents, II-antihypertensives and antialdobetica, hormone replacement therapy (systemic-Estrogens and progestogens), oral and postmenopausal ; statins. Also tell your prescriber if you have been using alcohol or street drugs or combining alcohol with the drug products that are being prescribed by your prescriber. More than 7 glasses of wine per week can affect the efficacy of the drug therapy. Do not start, stop, or change the dose of any drug without checking with your prescriber. Keep a list of all your medications (prescription, herbal, vitamins and non-prescription) and give it to any healthcare provider who treats you. Many other medicines that can be found over the counter contain aspirin or other medicines similar to Nizonide. Ask your prescriber or a healthcare provider if you are not sure. Mentioned is not an exhaustive list of Nizonide drug interactions. For further information contact your doctor.

Pregnancy and Breastfeeding

There are no data regarding the presence of Nizonide in human milk, the effects on the breastfed infant, or the effects on milk production. Nizonide and its metabolites are excreted in rat milk and accumulated in rat pups during lactation. The development and health benefits of breastfeeding should be considered along with the mother's clinical need for Nizonide and any potential adverse effects on the breastfed child from Nizonide or from the underlying maternal condition.

Nizonide should be avoided during pregnancy and lactation, unless, in the judgement of the physician, the potential benefits outweigh any potential risks. Nizonide showed no evidence of teratogenicity or embryotoxicity when administered to pregnant rats and rabbits during organogenesis at oral doses up to 500 mg/kg/day, about 4 times the recommended human dose on a mg/m2 basis. A fertility study in female rats revealed fetotoxicity associated with maternal toxicity at oral doses of 100 mg/kg/day, about 0.8 times the recommended human dose on a mg/m2 basis.

Side Effects

Laboratory findings: The effect of hepatic disease on the pharmacokinetics of single 500 mg doses of Nizonide was evaluated in 13 patients with mild to moderate hepatic impairment (7 alcoholic cirrhosis, 3 post-hepatitic cirrhosis, and 3 with more general hepatic disease) and seven age-matched, healthy control patients. Nizonide pharmacokinetic parameters following a single 500 mg dose of Nizonide were unchanged in the presence of the mild to moderate hepatic disease as compared to age-matched healthy subjects; however, the 48h post-dose urinary recovery of the major circulating Nizonide metabolite, tizoxanide (acylated conjugate), was significantly higher (p < 0.01) in the presence of mild or moderate hepatic impairment. No significant differences in the safety and tolerability of Nizonide between the healthy control group and the patients with hepatic disease receiving Nizonide were noted. Nizonide should be used to treat patients with hepatic impairment only if the benefits outweigh the risks.

Dizziness and somnolence: A number of reports of adverse events of Nizonide overdosage appear to be due to the symptoms of somnolence, impaired consciousness, stupor, coma, dizziness, and ataxia. There have been reports of headaches, abdominal pain, diarrhea, vomiting, and rashes. Symptoms of Nizonide overdosage should be treated symptomatically.

Patients should be informed that Nizonide can cause dizziness or somnolence. There have been reports of headache, abdominal pain, diarrhea, vomiting, and rash. An overview of the safety and tolerability of Nizonide based on pooled data from Phase II and III studies is presented below.

Common Side Effects

No drug has a universal effect, meaning it works in every person and is always safe. No two people are the same; your individual response to a certain medication differs. Similarly, the possible side effects of medication or risks of taking the medication differ from person to person. Some patients may experience side effects, while no side effects are experienced by others. A number of people may have three or four mild side effects, others may have a greater chance of experiencing severe side effects necessitating discontinuation of the medication, and also other reactions. Some of the most frequent side effects of NIZONIDE include: Mild to average headache, abdominal cramps, and vomiting of average intensity. Other more common mild to average adverse effects of NIZONIDE (occurring in 1% to 20% of all patients) include: mild to moderate tiredness, gentle dizziness, mild sleepiness, mild to moderate anxiety, indigestion, having to use the toilet more often, mild general discomfort, mild dizziness and loose stools that might happen only sometimes.

Side effects are issues related to drugs, but not necessarily caused by them. Certain side effects associated with drugs may occur. These might not be harmful but might be bothersome. For example, common side effects include upset stomach and diarrhea. An upset stomach can be misleading because the medication might not have been absorbed properly and will not be as effective. If the medicine upsets your stomach, taking it with food can help alleviate the discomfort. If diarrhea occurs, take fluids to replace those lost. Diarrhea might also be a sign of a new infection, particularly if it is accompanied by fever, chills, and prolonged or frequent episodes. These signs need to be reported to your healthcare provider. You should report all side effects, regardless of severity or nature, to your healthcare provider. Other remedies, such as changes of lifestyle, dose reductions, or administration of new medications, may be required by your healthcare provider.

Serious Side Effects

Generic Nizonide may affect liver function. A serious liver function disorder may occur with no obvious forewarning symptoms. Patients should be alert for signs and symptoms of liver problem. Like:

• Nausea or vomiting;
• Low stomach pains or tenderness on the right side of the stomach;
• Jaundice (yellow or dark urine) - Dark colored bowel movements (stool);
• A loss of appetite, tiredness, or lethargy;
• Itching on the skin (hives);
• Epileptic seizures or convulsions;
• Unconsciousness or loss of consciousness;
• Risk of harm to the kidney;
• Skin reactions (hives, blisters, or peeling);
• Liver problems including hepatitis, jaundice, and inflammation;
• Serious allergic reaction characterized by severe skin reaction with reddening, peeling, and swelling of the skin, swelling of the mouth, face, lips, or tongue, shortness of breath or difficulty in breathing, circulatory problems with rapid pulse, decreased arterial pressure, dermal rash with spots in case of purpura, hemorrhages, heart rhythm disorders or shock, collapse including hypotension, loss of consciousness, agitation, confusion, cramp, which may occur suddenly, erythema that can occur suddenly and any other signs of an allergic reaction.

Where to buy Nizonide (Nitazoxanide)

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Sources: Garza, K. et al. (2015) “Framing the community data system interface,” Proceedings of the 2015 British HCI Conference. British HCI 2015: 2015 British Human Computer Interaction Conference, ACM.